Fig. 8: lncRNA TCONS_00021785 can bind miR-21-5p to regulate Trim33. | Cell Death Discovery

Fig. 8: lncRNA TCONS_00021785 can bind miR-21-5p to regulate Trim33.

From: The lncRNA TCONS_00021785/miR-21-5p/Trim33 axis regulates VMP1-mediated zymophagy, reduces the activation of trypsinogen, and promotes acinar cell recovery

Fig. 8

A Construction of a co-expression network of LncRNA and mRNA; B predicted lncRNA TCONS_00021785 can bind miR-21-5p; C RT-PCR confirmed that lncRNA TCONS_00021785 was highly expressed in the AP cell model and the AP rat model; D, E detect the expression of miR-21-5p and Trim33; F detect the activation of trypsinogen in each group. G Its fluorescence intensity represents the activated trypsinogen. H When acinar cells are damaged by external stimuli, lncRNA TCONS_00021785 can competitively bind miR-21-5p to upregulate Trim33 (t-test, ***p < 0.001, **p < 0.01, *p < 0.05).

Back to article page