Fig. 1: GOLPH3 overexpression is significantly associated with colon cancer clinical-stage, TNM classification, and poor prognosis. | Cell Death Discovery

Fig. 1: GOLPH3 overexpression is significantly associated with colon cancer clinical-stage, TNM classification, and poor prognosis.

From: Golgi phosphoprotein 3 induces autophagy and epithelial–mesenchymal transition to promote metastasis in colon cancer

Fig. 1

A Western blotting analysis of GOLPH3 levels in colon cancer cell lines, including HCT-8, HT-29, HCT-116, SW480, and LOVO, and in the normal human colon epithelial cell line NCM460. β-actin served as the internal reference. Compared with the expression levels in NCM460 cells, colon cancer cell lines expressed high levels of GOLPH3. B Western blotting analysis of GOLPH3 levels in colon cancer tissues and paired non-cancerous adjacent tissue. GOLPH3 was upregulated in the four colon cancer tissues. C IHC staining of GOLPH3 in colon cancer tissues at different clinical stages. D Quantitative analysis of the data shown in C. GOLPH3 levels were positively correlated with clinical-stage. E Overall survival was analyzed using Kaplan–Meier analysis and the log-rank test; the level of GOLPH3 was negatively correlated with overall survival (P < 0.001). F, G Chi-square analysis: the differences in GOLPH3 levels between different clinical stages (P < 0.001) and T classification (P = 0.025), N classification (P < 0.001), and M classification (P = 0.009).

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