Fig. 1: WWP1 is downregulated in sepsis. | Cell Death Discovery

Fig. 1: WWP1 is downregulated in sepsis.

From: YTHDF1 alleviates sepsis by upregulating WWP1 to induce NLRP3 ubiquitination and inhibit caspase-1-dependent pyroptosis

Fig. 1

A The thermal map of differentially expressed genes in GSE100159 (12 normal control samples and 35 sepsis samples). B The intersection of UbiBrowser database and downregulated genes in GSE100159 dataset. C The expression of WWP1 in PBMCs collected from sepsis samples (n = 40) and healthy controls (n = 40) detected by RT-qPCR. D The survival rates of CLP-induced mice. E The pathological changes of lung, liver and kidney of CLP-induced mice observed by HE staining. F The expression of WWP1 in PBMCs of CLP-induced mice detected by RT-qPCR. There were ten mice in each group. **p < 0.01, ****p < 0.0001.

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