Fig. 4: WWP1 promoted the subcutaneous tumor growth of ICC cells in vivo. | Cell Death Discovery

Fig. 4: WWP1 promoted the subcutaneous tumor growth of ICC cells in vivo.

From: WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma

Fig. 4

A–C Subcutaneous tumor models were applied to explore the impact of WWP1 silencing on proliferation in vivo. A The images of tumors were generated in nude mice using WWP1 silenced HuCCT1 cells, n = 10. B The volumes and weights of subcutaneous tumors between WWP1 silencing and negative control groups. C HE and Ki-67 IHC staining images of subcutaneous tumors. D–F Subcutaneous tumor models were performed to detect the influence of WWP1 overexpression on proliferation in vivo. D The images of tumors were generated in nude mice using WWP1 overexpression RBE cells, n = 7. E The volumes and weights of subcutaneous tumors between WWP1 overexpression and vector groups. F HE and Ki-67 IHC staining images of subcutaneous tumors. **P < 0.01.

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