Fig. 7: Schematic diagram showing the mechanisms of NSUN5-FTH1/FTL.
From: The NSUN5-FTH1/FTL pathway mediates ferroptosis in bone marrow-derived mesenchymal stem cells
After added erastin, NSUN5 methylated FTH1/FTL mRNA by targeting on its 5′UTR/3′UTR region. NSUN5 recruits trap1 and binds to FTH1/FTL mRNA in BMSCs, and then induced to the degrade of FTH1/FTL. After FTH1/FTL is downregulated, it further promotes the low level of iron storage. Eventually, FTH1/FTL is maintained at an extremely low level, resulting in the accumulation of free ferrous ions, ROS levels, lipid peroxidation products and a reduction in the GPX4 and eventually leading to cell death due to ferroptosis.
