Fig. 6: Hyperglycemia deprives CSCs of primitive cells and alters their paracrine profile. | Cell Death Discovery

Fig. 6: Hyperglycemia deprives CSCs of primitive cells and alters their paracrine profile.

From: The impact of autophagy modulation on phenotype and survival of cardiac stromal cells under metabolic stress

Fig. 6

A Experimental timeline and design for autophagy modulation during hyperglycemia treatment. Quantification by flow cytometry of total Sca1+ (B) and Sca1+/CD90+/DDR2- (C) cells in the CSC population after 1 week of culture in 50 mM glucose, or 5 mM as control (n=3). D Heatmap with hierarchical clustering of Euclidean distance, calculated on Log2 values from normalized optical density of protein arrays on conditioned media from ad-ATG7 or ad-LacZ transduced CSCs exposed to 50 mM glucose; the heatmap is shown associated to the fold change (FC) histogram of ad-ATG7 versus ad-LacZ levels, for a selection of the most modulated cytokines. E Network of functional associations from the STRING database among cytokines of interest, showing only associations with edge confidence >0.7 (high/highest). *P<0.05, #P<0.0001.

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