Fig. 4: DM reversed the increased mitophagy, neuronal damage, cognitive deficits induced by hypoxia treatment.
From: Attenuated succinate accumulation relieves neuronal injury induced by hypoxia in neonatal mice
A–F Decreased immunoreactivity of LC3B (red), TOMM20 (green) in the EC after DM treatment. Blue, DAPI. G, H Fluorescence intensity of LC3B and TOMM20 in DG and EC. I–K The expression of activated caspase-3 and caspase-3 in the cortex and hippocampus detected by western blotting. L–N Positive FJB signals in DG and EC in each group. Bar = 50 μm, n = 5/group. O Latency to the platform (Two-way ANOVA). P Frequency of platform crossings. Q Target quadrant time (%), and (R) Opposite quadrant time (%). S Representative tracking. **P < 0.01, and ***P < 0.001, all compared with controls (One-way ANOVA). #P < 0.05, ##P < 0.01, and ###P < 0.001, compared with that in hypoxia+saline group (One-way ANOVA with Dunnett’s T3 post-hoc test).
