Fig. 5: MDM2 promotes CDDP resistance in uveal melanoma cells through regulation of the p53/IL5RA axis. | Cell Death Discovery

Fig. 5: MDM2 promotes CDDP resistance in uveal melanoma cells through regulation of the p53/IL5RA axis.

From: JMJD2C mediates the MDM2/p53/IL5RA axis to promote CDDP resistance in uveal melanoma

Fig. 5

A The expression of MDM2, p53, and IL5RA in MUM-2B and MUM-2B/CDDP cells with different treatments as measured by Western blot assay. B The viability and IC50 of MUM-2B and MUM-2B/CDDP cells with different treatments as examined by CCK-8 assay. C The senescence rate of MUM-2B and MUM-2B/CDDP cells with different treatments as assessed by SA-β-gal staining. D The migration and invasion abilities of MUM-2B and MUM-2B/CDDP cells with different treatment as examined by Transwell assay. * p < 0.05. Cell experiments were repeated three times independently.

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