Fig. 1: Effects of FMNL2 on cell migration and invasion of breast cancer in vitro and in vivo. | Cell Death Discovery

Fig. 1: Effects of FMNL2 on cell migration and invasion of breast cancer in vitro and in vivo.

From: FMNL2 suppresses cell migration and invasion of breast cancer: a reduction of cytoplasmic p27 via RhoA/LIMK/Cofilin pathway

Fig. 1

After transfection for 48 h, cultured cells were processed for indicated assays. A The protein levels of FMNL2 were measured by western blotting in human breast cancer cells. B The silencing efficiency and overexpression of FMNL2 were measured by western blotting in human breast cancer cells. C, D Representative images and quantified data of transwell assay were shown. Scale bar, 50 μm. E Representative lung metastasis in mice and HE staining of lung sections. Scale bar, 35 μm. F, G The levels of Vimentin and Snail were examined using qRT-PCR and western blotting. H The IHC staining for Vimentin and Snail in lung tissues was shown. Scale bar, 50 μm. *P < 0.05 versus corresponding control group.

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