Fig. 1: Dynamic changes of ATP6AP2 in the progression toward heart failure. | Cell Death Discovery

Fig. 1: Dynamic changes of ATP6AP2 in the progression toward heart failure.

From: ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation

Fig. 1

A, B Representative immunoblots of ATP6AP2 expression in the heart tissues from sham (n = 5) or TAC groups (n = 5 for each group) and quantitative analysis are shown. Statistical analysis was conducted by Kruskal–Wallis one-way ANOVA with Dunn post-hoc test. C Representative images of echocardiograms of sham and TAC mice at different timepoints. D Representative hematoxylin and eosin staining of cardiomyocyte staining (scale bar = 20 μm). E, F, I, J quantitative analysis of heart function of M-mode echocardiograms and heart rate. G Quantitative analysis of cardiomyocytes cross-sectional area. H Quantitative analysis of heart weight/body weight ratios (HW/BW; mg/g). Statistical analysis was conducted by Kruskal–Wallis one-way ANOVA with Dunn post-hoc test. Data were presented as medians and quartiles.

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