Fig. 3: Deletion of ATP6AP2 exacerbates progression of TAC-induced hypertrophy to heart failure in mice accompanying NLRP3 inflammasome expression upregulation. | Cell Death Discovery

Fig. 3: Deletion of ATP6AP2 exacerbates progression of TAC-induced hypertrophy to heart failure in mice accompanying NLRP3 inflammasome expression upregulation.

From: ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation

Fig. 3

A The gross morphology of mice hearts in different groups is shown. B, D, E, F, G Representative images of echocardiograms and quantitative analysis of LVEF, LVFS, LVEDD, and LVESD between different groups (n = 4 for each group). Statistical analysis was conducted by Kruskal–Wallis one-way ANOVA with Dunn post-hoc test. C, H Representative images of Masson trichrome staining of mice hearts and quantitative analysis. Statistical analysis was conducted by Kruskal–Wallis one-way ANOVA with Dunn post-hoc test. C, I, J Representative immunohistochemical staining and quantitative analysis about staining of NLRP3 and immunofluorescence images of SQSTM1/P62. Statistical analysis was conducted by Kruskal–Wallis one-way ANOVA with Dunn post-hoc test. K, L quantitative analysis of ELISA measurement of serum levels of IL-1β, TNF-α expression levels. Statistical analysis was conducted by Kruskal–Wallis one-way ANOVA with Dunn post-hoc test. Data were presented as medians and quartiles.

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