Fig. 1: RAD18 is high expression in TNBC and positively correlates with poor prognosis. | Cell Death Discovery

Fig. 1: RAD18 is high expression in TNBC and positively correlates with poor prognosis.

From: A positive feedback loop: RAD18-YAP-TGF-β between triple-negative breast cancer and macrophages regulates cancer stemness and progression

Fig. 1

RAD18 expression is frequently elevated in TNBC and associated with poor prognosis of TNBC patients. A RAD18 was relatively high expressed in breast cancer than any other cancer types. B The expression level of RAD18 was higher in TNBC tissues (n = 1097) compared to the surrounding normal tissues (n = 114). C, D RAD18 was especially high expression in TNBC according to TCGA database and GSE65194. E Kaplan–Meier survival analysis revealed that high RAD18 expression associated with a shorter overall survival (OS) compared to low RAD18 expression in TNBC patients (p = 0.0461). F Immunohistochemical analysis of RAD18 in 40 TNBC tissues samples (400×). G The expression of RAD18 was significantly higher in TNBC tissues (n = 40) than adjacent normal tissues (n = 10). The RAD18 expression level correlated with T tumor stages (nT1-T2=24, nT1-T2=16), but not with lymph node metastasis (nN0=25, nN1=15). H, I qRT-PCR and western blot showed that MDA-MB-231 and HCC-1806, as the TNBC cell lines, high expressed RAD18 compared to normal mammary epithelial cells (MCF-10A) and other breast cancer subtypes cell lines. *p < 0.05, **p < 0.01, ***p < 0.001.

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