Fig. 6: JTC-801 suppresses HCC progression through the NOP-autophagy pathway. | Cell Death Discovery

Fig. 6: JTC-801 suppresses HCC progression through the NOP-autophagy pathway.

From: The nociceptin receptor promotes autophagy through NF-kB signaling and is transcriptionally regulated by E2F1 in HCC

Fig. 6

A CCK-8 and colony-formation assays showing the proliferation of HCC cells treated with various concentrations of JTC801. B CCK-8 and colony-formation assays showing the proliferation of HCC cells treated with various concentrations of nociceptin. C CCK-8 assay and apoptosis analysis showing the proliferation of shNC and shNOP HCC cells treated with DMSO, JTC-801 or nociceptin. D IB analysis of the indicated proteins associated with NF-kB, autophagy, and apoptosis in Huh7 cells treated with JTC-801 or nociceptin. E IF staining showing LM3 expression in shNC and shNOP HCC cells treated with JTC-801 or nociceptin. Scale bars = 20 μm. F shNC and shNOP HCC cell-derived xenograft tumors in mice treated with JTC-801 or nociceptin. ***P < 0.001, **P < 0.01, *P < 0.05.

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