Fig. 4: Inhibition of BKCa channel protects the neonatal heart from ischemia injury. | Cell Death Discovery

Fig. 4: Inhibition of BKCa channel protects the neonatal heart from ischemia injury.

From: Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury

Fig. 4

A Schematics of the ischemia-reperfusion protocol. Rat P6 pup hearts were subjected to 20 min ischemia, 5 min post-conditioned with DMSO, Iberiotoxin (100 nM), or NS1619 (10 μM) followed by 60 min of reperfusion. Hearts post-conditioned with C and E iberiotoxin exhibited significantly less infarction (white) as compared to the B and E DMSO control. In hearts post-conditioned with NS1619 displayed significantly higher infarction compared to DMSO control and IbTx treatment (E). The current versus voltage relationships are plotted with or without iberiotoxin (F). Data represented as mean ± SEM for percentage infarction from four independent experiments and electrophysiology data represented from four independent litters P6 rat pups. P-values were determined by a one-tailed paired student’s t-test; *≤ 0.05, ***≤ 0.0001.

Back to article page