Fig. 2: The expression levels of miR-199a-1-5p are significantly increased in POL and POL-EXO, and is enhanced in the OL upon uptaking of POL-exo. | Cell Death Discovery

Fig. 2: The expression levels of miR-199a-1-5p are significantly increased in POL and POL-EXO, and is enhanced in the OL upon uptaking of POL-exo.

From: Low-metastatic melanoma cells acquire enhanced metastatic capability via exosomal transfer of miR-199a-1-5p from highly metastatic melanoma cells

Fig. 2

A Imaging analysis of the time course of OL uptake of exosomes secreted by POL-N.C., bar = 10 μm. Wien diagram (B) and Heat map analysis (C) of miRNAs secreted by OL and POL cells. D Differentially expressed miRNAs between POL-exo and OL-exo. miR-199a-1-5p expression in OL-exo and POL-exo (E) and in OL and POL cells (F) evaluated by RT-qPCR. ***P < 0.001. G miR-199a-1-5p expression in POL-N.C. and POL-miR-199a-1-5p-mimics evaluated by RT-qPCR. ***P < 0.001. H Imaging analysis of the time course of OL uptake of exosomes secreted by POL-miR-199a-1-5p-mimics cells, bar = 10 μm. Wien diagram. I miR-199a-1-5p expression in OL + PBS and OL + POL-miR-199a-1-5p-mimics-Exo evaluated by RT-qPCR. *P < 0.05. J TCGA analysis of miR-199a-1-5p gene relative expression in melanoma. K–P The Kaplan-plot of miR-199a-1-5p gene in patients with melanoma.

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