Fig. 3: Overexpression of miR-199a-1-5p expression effectively enhanced the metastatic colonization ability of OL in vitro and in vivo. | Cell Death Discovery

Fig. 3: Overexpression of miR-199a-1-5p expression effectively enhanced the metastatic colonization ability of OL in vitro and in vivo.

From: Low-metastatic melanoma cells acquire enhanced metastatic capability via exosomal transfer of miR-199a-1-5p from highly metastatic melanoma cells

Fig. 3

A miR-199a-1-5p expression in OL-N.C. and OL-miR-199a-1-5p-OE evaluated by RT-qPCR. ***P < 0.001. Visualization (B, bar = 60 μm) and quantitative analysis of (C, ***P < 0.001) the migration ability of OL-N.C. and OL-miR-199a-1-5p-OE cells. Visualization (D, bar = 60 μm) and quantitative analysis of (E, ***P < 0.001) of the invasive ability of OL-N.C. and OL-miR-199a-1-5p-OE Cells. Visualization (F) and quantitative analysis (G, ***P < 0.001) of the clonogenic ability of OL-N.C. and OL-miR-199a-1-5p-OE cells. H Analysis of the effect of miR-199a-1-5p overexpression on metastatic colonization in vivo. I The weight changes of mouse injected with OL-N.C. and OL-miR-199a-1-5p-OE cells. J H&E staining of metastatic nodules in the lungs, bar = 5 mm.

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