Fig. 6: SNORD1C was upregulated in CRC, which activated the canonical Wnt/β-catenin pathway and promoted the development of cancer stem cells. | Cell Death Discovery

Fig. 6: SNORD1C was upregulated in CRC, which activated the canonical Wnt/β-catenin pathway and promoted the development of cancer stem cells.

From: SNORD1C maintains stemness and 5-FU resistance by activation of Wnt signaling pathway in colorectal cancer

Fig. 6

Together, these increased β-catenin expression and that of the transcription factor TCF7, which led to increased expression of the target gene MYC. Furthermore, binding to the stem cell regulator SOX2 promoted cancer development and enhanced chemotherapy resistance.

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