Table 1 Pyroptosis is closely related to the progression of inflammation to cancer.
Molecule/drug | Cancer type | Biological function | Mechanism | Refs |
|---|---|---|---|---|
SMS1 | NASH | Suppression of tumor growth | Activates the NLRC4 inflammasome and caspase-1 | [63] |
GSDMD | NASH | Induction of cancer | Activates NF-kB and causes steatosis and cell pyroptosis | [62] |
E2 | HCC | Induction of cancer | Activates the NLRP3 inflammasome | [66] |
HBx | Hepatitis B | Induction of cancer | Activates the NLRP3 inflammasome and promotes pyroptosis | [58] |
HCV | Hepatitis C | Induction of canc | Promotes pyroptosis | [65] |
Sorafenib | HCC | Suppression of tumor growth | Induces macrophage (MΦ) pyroptosis | [67] |
BI2536 | ESCC | Inhibition of cancer | Activates GSDME and induces pyroptosis | [86] |
Metformin | ESCC | Suppression of tumor growth | Promotes pyroptosis | [88] |
GSDMD | BE | Induction of cancer | Secretes inflammatory cytokines and chemokines | [82] |
Alcohol | Esophagitis | Induction of cancer | Activates caspase-1 | [81] |
GSDMD | Gastric cancer | Suppression of tumor growth | Promotes pyroptosis | [83] |
GSDME | Gastric cancer | Inhibition of tumor growth | Activates caspase-3 and cause pyroptosis | [87] |
MST1 | PDAC | Suppression of tumor growth | Induces pyroptosis via ROS | [84] |
KJL | UC | Alleviation symptoms | Inhibits the occurrence of pyroptosis | [75] |
HMGB1 | CAC | Induction of cancer | Cleaves GSDME and releases HMGB1 | [32] |
IRGM | Colitis | Suppression of tumor growth | Inhibits NLRP3 inflammasome activation and pyroptosis | [76] |
NALP1 | Colon cancer | Suppression of tumor growth | Triggers pyroptosis | [79] |
LXRb | Colon cancer | Inhibition of tumor growth | Induces pyroptosis by activating caspase-1 | [77] |
lobaplatin | Colon cancer | Inhibition of cancer | Regulates GSDME and trigger pyroptosis | [78] |
