Fig. 2: Inhibition of ENO1 reversed the effect of lactate on the growth of LM3 organoids. | Cell Death Discovery

Fig. 2: Inhibition of ENO1 reversed the effect of lactate on the growth of LM3 organoids.

From: Lactate promotes the growth of patient-derived organoids from hepatopancreatobiliary cancers via ENO1/HIF1α pathway and does not affect their drug sensitivities

Fig. 2

A Bright-field images of LM3 organoids treated with 20 mM lactate or AP-III-a4. Scale bars in ×100 row refer to 200 μm and scale bars in ×200 row refer to 100 μm. B Viability of LM3 organoids treated with 20 mM lactate or AP-III-a4. C Immunoblot showing bands corresponding to HIF1α, PI3K, p-PI3K, AKT, p-AKT, and β-actin. D Quantification of the above proteins, p-PI3K/PI3K ratio, and p-AKT/AKT ratio in the indicated groups. *P < 0.05.

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