Fig. 3: The signaling mechanism of the effects of ANGPTL4 on OS growth by RNA-seq. | Cell Death Discovery

Fig. 3: The signaling mechanism of the effects of ANGPTL4 on OS growth by RNA-seq.

From: ANGPTL4 negatively regulates the progression of osteosarcoma by remodeling branched-chain amino acid metabolism

Fig. 3

A, B Volcano plots of the differentially expressed genes (DEGs) in the MNNG-A4 cells, MNNG-siA4 cells, and control cells. Fold change values on the X-axis were log2-transformed while p values on the Y-axis were −log10 transformed. The screening criteria for DEGs were p value <0.05 and expression level higher than 1.5-fold or lower than 0.67-fold. C, D KEGG pathway enrichment analysis for DEGs in the MNNG-A4 cells, MNNG-siA4 cells, and control cells. E Heatmap of the BCAA-associated DEGs between the ANGPTL4-regulated cells and the control cells. F The protein-protein interaction network provided interactive information for the branched-chain amino acid (BCAA)-associated DEGs.

Back to article page