Fig. 6: Effect of Pin1/BRD4 axis on lung metastasis of GC induced by hyperglycemia.
From: Hyperglycemia induces gastric carcinoma proliferation and migration via the Pin1/BRD4 pathway
a Stable ShPin1 or Sh-NC MKN45 cells were injected into the tail vein of nude mice. In vivo tumor lung metastasis in tumor xenografts were assessed using bioluminescence imaging 24 days after injection. Lung metastases of the nude mice were quantified and measured as average radiance (p/s/cm2/sr). Values are mean ± SEM (n = 4); **P < 0.01 vs. Ctrl+Sh-NC; ##P < 0.01 vs. DM + Sh-NC. b Lung tissues were stained with HE to observe lung metastasis nodules. Scale bars, 100 μm and 200 μm. The histogram shows the number of lung metastasis nodules. Values are mean ± SEM (n = 4). **P < 0.01 vs. Ctrl+Sh-NC; ##P < 0.01 vs. DM + Sh-NC.
