Fig. 1: Macrophage infiltration increases in renal interstitium in cisplatin-induced AKI murine model. | Cell Death Discovery

Fig. 1: Macrophage infiltration increases in renal interstitium in cisplatin-induced AKI murine model.

From: TLR2/caspase-5/Panx1 pathway mediates necrosis-induced NLRP3 inflammasome activation in macrophages during acute kidney injury

Fig. 1

C57/BL mice were administered by intraperitoneal injection of cisplatin (25 mg/kg) and sacrificed 3 days later. Representative PAS staining images and immunohistochemical images F4/80 staining. Asterisk indicates injured renal tubules and white arrow indicates infiltrated macrophages. (scale bar, 100 μm) (A). Tubular injury score assessed in each group (B). Quantification of F4/80-positive cells by digital image analysis (C). Relative mRNA expressions of KIM-1 and NGAL in the renal tissue (D). Relative mRNA expressions of IL-1β in the renal tissue (E). Data are presented as the mean ± SD. n = 6 mice per group. The p values were calculated using Students t test. ***p < 0.001.

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