Fig. 8: Schematic illustrating the proposed mechanism by which danger signals from necrotic TECs activate NLRP3 inflammasome in macrophages. | Cell Death Discovery

Fig. 8: Schematic illustrating the proposed mechanism by which danger signals from necrotic TECs activate NLRP3 inflammasome in macrophages.

From: TLR2/caspase-5/Panx1 pathway mediates necrosis-induced NLRP3 inflammasome activation in macrophages during acute kidney injury

Fig. 8

We propose that danger signals from necrotic TECs can bind with TLR2 in macrophages, which upregulates caspase-5 and trigger Panx1 cleavage. Intracellular ATP released from macrophages through Panx1 channel can stimulate P2RX7 and cause the activation of NLRP3 inflammasome to produce IL-1β.

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