Table 2 Caspase-5 functional partners depicted by STRING.

From: TLR2/caspase-5/Panx1 pathway mediates necrosis-induced NLRP3 inflammasome activation in macrophages during acute kidney injury

Protein

Function

Combined_Score

TLR2

Toll-like receptor 2

0.459

PANX1

Pannexin-1

0.527

P2RX7

P2X purinoceptor 7

0.507

NLRP3

NACHT, LRR and PYD domains-containing protein 3

0.985

PYCARD(ASC)

Apoptosis-associated speck-like protein containing a CARD

0.996

CASP-1

Caspase-1

0.937

IL1B

Interleukin-1 beta

0.81

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