Fig. 2: hsa-miR-27a-3p is transferred into macrophages from GBM cells via EVs. | Cell Death Discovery

Fig. 2: hsa-miR-27a-3p is transferred into macrophages from GBM cells via EVs.

From: microRNA-27a-3p delivered by extracellular vesicles from glioblastoma cells induces M2 macrophage polarization via the EZH1/KDM3A/CTGF axis

Fig. 2

A Differential expression of hsa-miR-27a-3p in microarray GSE65626. The X-axis represents sample type, and the Y-axis represents expression value. Gray box indicates normal samples (n = 3), while red box indicates tumor samples (n = 3). B RT-qPCR results of hsa-miR-27a-3p expression in clinical samples of patients with GBM (n = 50) and non-GBM patients (n = 20). C RT-qPCR results of hsa-miR-27a-3p expression in macrophages exposed to GBM-EVs relative to normal macrophages. D RT-qPCR results of hsa-miR-27a-3p expression in macrophages cultured under normoxia/hypoxia conditions following co-culture with GBM-EVs. *p < 0.05 compared with normal tissues, normal cells or macrophages treated with mimic-NC. #p < 0.05 compared with macrophages treated with GBM-EVs-inhibitor NC. The experiment was repeated 3 times independently.

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