Fig. 8: Schematized molecular mechanism underlying hsa-miR-27a-3p contained in GBM-EVs.

EV hsa-miR-27a-3p inhibits the mRNA expression of target gene EZH1 to upregulate KDM3A-mediated CTGF mRNA expression, which induces M2 macrophage polarization and further facilitates proliferation, migration and invasion of GBM cells.