Fig. 4: circDHTKD1 promotes lymphangiogenesis and LN metastasis of BCa.
From: circDHTKD1 promotes lymphatic metastasis of bladder cancer by upregulating CXCL5
A and B Tube formation and Transwell migration of HLEC cultured with conditioned medium derived from circDHTKD1-upregulated or control BCa cells. C and D Tube formation and Transwell migration of HLEC cultured with conditioned medium from circDHTKD1-downregulated or control BCa cells. Scale bars, 100 µm. E An image of the popliteal LN metastasis model. Black arrow indicated the footpad tumor and popliteal LN. F Representative images of excised popliteal LNs and the measurement of the LN volume. G Kaplan–Meier analysis evaluating the survival. Error bars indicate standard deviations of three independent experiments. *p < 0.05 and **p < 0.01.
