Fig. 7: CXCL5-activated neutrophils induce lymphangiogenesis.
From: circDHTKD1 promotes lymphatic metastasis of bladder cancer by upregulating CXCL5
A Chemotaxis of neutrophils induced by conditioned medium from BCa cells. B VEGF-C expression in neutrophils induced by conditioned medium was detected by qRT-PCR. C Neutrophils in footpad tumors in the indicated mouse group were evaluated by HE and IHC staining. Black arrows indicate the infiltrated neutrophils in footpad tumors. Scale bars, 50 µm. D Tube formation and Transwell migration of HLEC cultured with conditioned medium from neutrophils induced by indicated BCa cells. Scale bars, 100 µm. Error bars indicate standard deviations of three independent experiments. *p < 0.05 and **p < 0.01.
