Fig. 6: SMYD2 promotes the progression of GIST in vivo by mediating the EZH2/TET1 axis.
From: SMYD2 aggravates gastrointestinal stromal tumor via upregulation of EZH2 and downregulation of TET1
The nude mice were treated with sh-NC, sh-TET1, sh-NC + LLY-507, sh-TET1 + LLY-507, sh-NC + AZ-505, or sh-TET1 + AZ-505. A Weight of tumors. B Volume of tumors. C SA-β-gal detection of cell senescent in tumor tissues, scale bar: 50 μm. D TUNEL detection of apoptotic cells in the tumor tissues, scale bar: 50 μm. *p < 0.05 vs. sh-NC-treated mice, #p < 0.05 vs. mice treated with sh-NC + LLY-507 or sh-NC + AZ-505. Measurement data were expressed as mean ± standard deviation. One-way ANOVA with Tukey’s post-hoc test was used to compare multigroup data whereas repeated-measures ANOVA was utilized to compare multigroup data at different time points, followed by Tukey’s post-hoc test. n = 5 mice/group.
