Fig. 7: The graphical summary of the function and mechanism of SMYD2.
From: SMYD2 aggravates gastrointestinal stromal tumor via upregulation of EZH2 and downregulation of TET1
SMYD2 elevates the expression of EZH2, promotes the methylation level of H3K27me3 in the promoter region of TET1, and reduces the expression of TET1, thus accelerating the occurrence and development of GIST.
