Fig. 2: The roles of YTHDC1 in embryonic stem cells.
From: Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases
YTHDC1 mediates the self-renewal and represses the 2-cell-like transcription program in mouse embryonic stem cells by recognizing m6A modified LINE1 RNAs on chromatin and facilitating the formation of LINE1-NCL-KAP1 complex to regulate H3K9me3 level on 2-cell-related retrotransposons and repress the 2-cell program.
