Fig. 4: Transcriptome analysis of MuSCs upon TET2 loss.
From: Disturbance of calcium homeostasis and myogenesis caused by TET2 deletion in muscle stem cells
A The volcano plot of DEGs (TET2-KO versus WT). B Heatmap of the expression level of DEG. C Gene ontology analysis of downregulated gene in TET2 KO group. D Gene ontology analysis of upregulated gene in TET2 KO group. E Heatmap of the most down-regulated genes. F The fluorescence labeling of Fluo-3 probe in the MuSCs of TET2-KO and WT group (Scale bars, 100 μm). G Quantification of the intensity of Fluo-3 (n = 6 biological samples) and relative expression levels of calcium-signaling related genes in WT and TET2-KO MuSCs (n = 3 biological samples). Error Bar indicated SEM. ** indicated that p < 0.01, *** indicated that p < 0.001.
