Fig. 4: Both miR-27a and miR-27b could reverse the tumor metastasizing-effects of circRFWD3 in HNSCC cells.
From: CircRFWD3 promotes HNSCC metastasis by modulating miR-27a/b/PPARγ signaling
A, C Transwell assays indicated that the migration ability of UM1 and HN31 cell were observably restricted by transfection of miR-27a and miR-27b mimics. B, D Transwell assays indicated that the invasive capabilities of UM1 and HN31 cell were observably restricted by transfection of miR-27a and miR-27b mimics. E–H Transwell assays revealed that miR-27a and miR-27b inhibitors could rescue the inhibitory effects of circRFWD3 knockdown of migration and invasion in UM1 and HN31 cells. Scale bar, 100 μm. data were shown as the mean value ± SD of three independent experiments. The asterisks indicate significant differences (Student’s t-tests, *P < 0.05, **P < 0.01, ***P < 0.001).
