Fig. 7: Schematic diagram of the regulation of c-MYC by PAX8. | Cell Death Discovery

Fig. 7: Schematic diagram of the regulation of c-MYC by PAX8.

From: Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5

Fig. 7

In TP53 wild-type cells, a small amount of PAX8 is insufficient to co-regulate the transcriptional level of c-MYC with DDX5, while in TP53-mutated cells, promoter hypomethylation leads to high expression of PAX8, which in turn cooperates with DDX5, possibly by unraveling the Myc4G structure leading to increased c-MYC expression and promotes cell cycle progression.

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