Fig. 2: The dual control model for MOMP.
From: Severe cellular stress drives apoptosis through a dual control mechanism independently of p53
In response to severe cellular stress, sensitizers might disentangle Bax/Bak from anti-apoptotic proteins such as Bcl2 or Bcl-xl and then activators might prompt the formation of Bax/Bak pore for MOMP in p53-independent manner. These sensitizers might be BH3-only proteins, nevertheless these activators might be also BH3-only proteins or the factors other than BH3-only protein.
