Fig. 1: CC-115 induces cytotoxic, anti-proliferative and cytostatic activity in primary human NSCLC cells.
From: An mTOR and DNA-PK dual inhibitor CC-115 hinders non-small cell lung cancer cell growth
pCan1 cells were treated with CC-115 at the applied concentrations (10–300 nM) and were cultivated for the designated time periods; Cell viability (CCK-8 OD, A), colony formation (colony number was quantified, B), cell death (by measuring Trypan blue-positive cell ratio, C) and proliferation (by testing nuclear EdU percentage, D), cell cycle progression (PI flow cytometry assays, E), cell migration (“Transwell” studies, F) and invasion (“Matrigel Transwell” studies, G) were tested. “Veh” stands for the vehicle control (same all for Figures). For each assay, n = 5. *P < 0.05 versus “Veh” group. Scale bar = 100 μm (D, F and G).
