Fig. 4: CC-115 simultaneously blocks mTORC1/2 and DNA-PKcs activation.
From: An mTOR and DNA-PK dual inhibitor CC-115 hinders non-small cell lung cancer cell growth
pCan1 or pCan2 cells were treated with CC-115 (100 nM), and cultivated for the designated time periods, expression of listed proteins was shown A, C; The relative DNA-PK activity was measured as well B. pCan1 or pCan2 cells were treated with CC-115 (100 nM), AZD2014 (100 nM), NU7026 (100 nM) or AZD2014 plus NU7026, and cells were further cultivated for 96 h; Cell viability and death were measured via the CCK-8 D and the Trypan blue staining E assays, respectively. For each assay, n = 5. *P < 0.05 versus “Veh” group. #P < 0.05 versus “CC-115” group. “n.s.” stands for non-statistical difference. .
