Table 1 Characteristics of similarities and differences in pyroptosis, apoptosis and necroptosis.
From: Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer
Characteristics | Pyroptosis | Apoptosis | Necroptosis |
|---|---|---|---|
Programmed cell death | + | + | + |
Membrane rupture | + | − | + |
Selective channels | − | − | + |
Nonselective pore formation | + | − | − |
Membrane blebbing | + | + | − |
Osmotic lysis | + | − | + |
DNA damage | + | + | + |
Organelle swelling | − | − | + |
Chromatin condensation | + | + | − |
Caspase-1/4/5/11 activation | + | − | − |
Caspase-2/7/10 activation | − | + | − |
Caspase-3/6/8/9 activation | + | + | − |
EtBr staining | + | − | + |
PI staining | + | − | + |
7-AAD staining | + | − | + |
Annexin V staining | + | + | + |
TUNEL staining | + | + | + |
Cell swelling | + | − | + |
Cell shrink | − | + | − |
Intact nucleus | + | − | + |
Pyroptotic bodies | + | − | − |
Apoptotic bodies | − | + | − |
Necroptotic bodies | − | − | + |
Inflammation | + | − | + |
PARP cleavage | + | + | − |
Gasdermin cleavage | + | − | − |
ROCK1 cleavage | − | + | − |
Phosphorylation of MLKL/RIP3 | − | − | + |
