Fig. 1: Trp53 signature is gradually decreased during chondrogenesis and embryonic bone development. | Cell Death Discovery

Fig. 1: Trp53 signature is gradually decreased during chondrogenesis and embryonic bone development.

From: Trp53 controls chondrogenesis and endochondral ossification by negative regulation of TAZ activity and stability via β-TrCP-mediated ubiquitination

Fig. 1

A Trp53 expression was identified in the primary chondrocytes using the publicly available early murine limb development data from GSE30138 [29] as indicated. E: embryonic day. B Representative immunofluorescent image of Trp53 in the tibia from wild-type mice as shown. P0: the newborn. Scale bars, 75 μm. C Trp53 expression in cartilage as indicated. P: postnatal day. D, E Trp53 expression was determined by qRT-PCR and western blot after culture as indicated time in chondrogenic differentiation medium. D: day. *P < 0.05, **P < 0.01, ***P < 0.001.

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