Fig. 3: Trp53 deficiency in chondrocytes promotes bone formation. | Cell Death Discovery

Fig. 3: Trp53 deficiency in chondrocytes promotes bone formation.

From: Trp53 controls chondrogenesis and endochondral ossification by negative regulation of TAZ activity and stability via β-TrCP-mediated ubiquitination

Fig. 3

A Representative micro-CT reconstruction as indicated at 2 months. N = 5. Scale bars, 1 mm. B–E Histomorphometric analysis of bone parameters from (A) as shown. F Representative H&E images of femur sections from 2-month-old Col2-Cre;Trp53f/f mice and controls. N = 5. Scale bar, 1 mm. G Osteoblast number per bone perimeter. H Osteoblast surface per bone surface (osteoblast surface/BS). I–K Representative image of double calcein labeling in the tibia from 2-month-old Col2-Cre;Trp53f/f mice and controls. Scale bar, 50 μm. L TRAP staining. Scale bar, 50 μm. M Osteoclast No./BS. N Osteoclast surface/BS. **P < 0.05.

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