Fig. 5: Hif1α participates in E2 induced down-regulation of c-myb and neutrophil hyperplasia. | Cell Death Discovery

Fig. 5: Hif1α participates in E2 induced down-regulation of c-myb and neutrophil hyperplasia.

From: Estrogens revert neutrophil hyperplasia by inhibiting Hif1α-cMyb pathway in zebrafish myelodysplastic syndromes models

Fig. 5

A Double staining of hif1α and c-myb-GFP with antibodies with or without E2 treatment. B Knockdown (MO) or inhibition (PX-478) of hif1α decreased c-myb and lyz expression by WISH as well as SB positive neutrophils in c-mybhyper zebrafish. (t-test, ***p < 0.001, **p < 0.01, *p < 0.05, n > 20). C Overexpression of hif1α reversed E2 induced down-regulation of c-myb and lyz expression by WISH and neutrophil hyperplasia by SB staining. (t-test, ***p < 0.001, **p < 0.01, *p < 0.05, n > 20).

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