Fig. 2: Inhibitors of TWEAK/Tnfrsf12a axis attenuates ALF induced by TAA or APAP. | Cell Death Discovery

Fig. 2: Inhibitors of TWEAK/Tnfrsf12a axis attenuates ALF induced by TAA or APAP.

From: Inhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis

Fig. 2

A, B Representative macroscopic appearance of livers at 24 h following TAA or APAP treatment in the presence or absence of TWEAK/Tnfrsf12a axis inhibitors. C, D Representative H&E-stained liver sections. Scale bars, 100 μm. E, F Suzuki score of H&E-stained liver sections (n = 5; mean ± s.d.). P values were determined by Student’s t test (*P < 0.05; ****P < 0.0001). G, H Serum levels of ALT and AST(U/L) (n = 6; mean ± s.d.). P values were determined by Student’s t test (**P < 0.01; ***P < 0.001; ****P < 0.0001; ns, not significant). I, J Representative TUNEL-stained liver sections. Scale bars, 100 μm. K, L Percentage of TUNEL positive cells in liver sections (n = 5; mean ± s.d.). P values were determined by Student’s t test (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001). All experiments were repeated at least two times.

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