Fig. 6: RBCK1 exerts oncogenic effects partially through regulating RNF31.
From: RBCK1 promotes hepatocellular carcinoma metastasis and growth by stabilizing RNF31
A The efficacy of reintroducing shRBCK1 into HCC cells that stably overexpressed exogenous RNF31 was evaluated via western blot. B RNF31 impaired the HCC cell’s inhibition of migration and invasion induced by RBCK1 knockdown in PLC/PRF/5 and huh-7 cells as confirmed by migration and invasion assays. C RNF31 abolished the proliferation inhibition of HCC cells imposed by RBCK1 knockdown in PLC/PRF/5 and huh-7 cells as confirmed by CCK-8 assays. D RNF31 abolished the HCC cell’s suppression of proliferation caused by RBCK1 knockdown in PLC/PRF/5 and huh-7 cells as confirmed by a colony formation assay. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).
