Table 1 Significance of COX6c in various diseases.
From: Novel role of COX6c in the regulation of oxidative phosphorylation and diseases
Disease | Model | COX6c | Significance | Reference |
|---|---|---|---|---|
Cardiovascular | Familial hypercholesterolemia | Differentially expressed gene (↓) | Prediction of genetic risk factors of atherosclerosis; A potential therapeutic target | [40] |
Kidney | Diabetic nephropathy | Differentially expressed gene (↑) | Telmisartan can downregulate COX6c and improve kidney function of diabetic | |
ESRD/HD | Expression ↓ | A promising therapeutic target | [25] | |
ESRD/HD | Expression ↓ | A negative correlation with oxidative stress | [28] | |
ESRD/PD | Expression ↓ | An indicator of mitochondrial oxidative metabolism | [48] | |
Brain | Alzheimer’s disease | Expression ↓ Activity ↓ | Secondary event in brain areas associated with impaired metabolic activity and neuronal loss | |
Ischemia | Expression ↑ | Compensatory effect to restore OXPHOS | [51] | |
Skeletal muscle | Contusion | Expression changes in a regular way | Diagnosis reliability in wound age estimation | |
Acute COPD exacerbation | Expression ↓ | Downregulation of OXPHOS pathway; Upregulation of apoptosis pathway | [55] | |
Tumor | Prostate cancer | Expression ↑ | A useful marker to study the alteration of energy metabolism in cancer cells; Diagnosis | [56] |
Drug resistance in breast cancer | Expression ↑ | A compensating mechanism to maintain mitochondrial function to serve as a survival mechanism to overcome drug resistance | [60] | |
Breast cancer | Expression ↓ | Striking toxicity and acceleration of cell death | ||
Breast cancer | Expression ↓ | Discriminating hormone-responsive breast cancer Predicting patient survival | [65] | |
Follicular thyroid cancer | COX6c/DERL2 translocation | Tumor diagnostics | [66] | |
Uterine myomas | COX6c/HMGIC translocation | Tumor diagnostics | ||
Retroperitoneal lipoma | Chromosome arrangement | Tumor diagnostics | [69] |
