Fig. 5: POLRMT overexpression exerts pro-cancer activity in primary skin SCC cells.
From: The mitochondrial RNA polymerase POLRMT promotes skin squamous cell carcinoma cell growth
C1 primary skin SCC cells expressing the lentiviral POLRMT-expressing construct (oePOLRMT-sL1 and oePOLRMT-sL2, representing two stable selections) or the empty vector (“Vec”) were established, expression of listed genes and proteins was shown (A–C); Cells were further cultivated for applied time periods, cell viability, proliferation and migration were tested by CCK-8 (D), nuclear EdU staining (E) and “Transwell” (F) assays, respectively. *P < 0.05 versus “Vec” cells. Scale bar = 100 μm (E, F).
