Fig. 6: METTL3 reduced FFA levels and improved IR in CIH rats. | Cell Death Discovery

Fig. 6: METTL3 reduced FFA levels and improved IR in CIH rats.

From: Intermittent hypoxia-induced METTL3 downregulation facilitates MGLL-mediated lipolysis of adipocytes in OSAS

Fig. 6

A The HE staining and immunohistochemical staining of METTL and MGLL on adipose tissues from OSAS patients and non-OSAS donors. B The schematic diagram of CIH rats construction and adenovirus injection. C The levels of serum FFAs were enhanced in CIH rats and reduced by adenovirus overexpressing METTL3. D The levels of glucose tolerance detected by GTT were decreased in CIH rats and improved by adenovirus overexpressing METTL3. E The levels of insulin sensitivity detected by ITT were decreased in CIH rats and improved by adenovirus overexpressing METTL3. F The HOMA-IR was increased in CIH rats and reduced by adenovirus overexpressing METTL3; n = 4, *P < 0.05, **P < 0.01, ns indicates not significant. M3 means treatment of adenovirus overexpressing METTL3.

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