Fig. 8: Volcano plot of differentially expressed genes from TSA-induced ADM reversal in KC mouse acini. | Cell Death Discovery

Fig. 8: Volcano plot of differentially expressed genes from TSA-induced ADM reversal in KC mouse acini.

From: Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia

Fig. 8

KC mouse pancreatic acini underwent ADM over 2 days of culture and were then exposed to 500 nM of TSA for 2 additional days. RNA isolated from the treated and day 6 untreated control were subjected to Illumina NovaSeq6000 whole transcriptome sequencing. Shown are the expression of a selected set of 82 genes which are the mouse equivalents to those previously identified as associated with the pancreatic acinar/ductal phenotype or genes associated with the onset or progression of PDAC as described in the “Methods” section.

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