Fig. 3: DSF ameliorated lupus-associated manifestations in PIL mice.
From: Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis
PIL mice were treated with a dose of 50 mg/kg DSF or equivalent sterile saline for 14 weeks. A Proteinuria of mice in each group was assessed using Albustix test every 2 weeks. B The level of serum anti-dsDNA antibodies was examined by ELISA. C Representative photographs of the kidneys from each group by H&E staining. Inflammatory cell infiltration was with black arrows, and mesangial cell proliferation was with white arrow. D Austin scores of kidneys from each group. E, F Representative images in glomeruli of kidneys from each group stained for the deposition of IgG and C3. n = 8 animals for each group. *p < 0.05, **p < 0.01, ***p < 0.001. PIL pristane-induced lupus, IgG immunoglobulin G, C3 Complement 3.
