Fig. 4: DSF reduced the level of serum IL-1β and inhibited glomerular macrophage pyroptosis in PIL mice. | Cell Death Discovery

Fig. 4: DSF reduced the level of serum IL-1β and inhibited glomerular macrophage pyroptosis in PIL mice.

From: Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis

Fig. 4

A Representative immunohistochemical staining images of NLRP3, caspase-1, cleaved caspase-1 and GSDMD in the kidneys. B Double immunofluorescence staining of glomerular macrophages (green) and GSDMD (red) in each group. F4/80 represented macrophages. C GSDMD in monocytes/macrophages as a proportion of total GSDMD was calculated. D The level of serum IL-1β in each group was detected by ELISA. n = 8 animals for each group. Each experiment was repeated three times. Significant differences were calculated using one-way ANOVA. Values were shown as mean ± SD. **p < 0.01, ***p < 0.001. PIL pristane-induced lupus. DAPI 4′, 6-diamidino-2-phenylindole.

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