Fig. 3: RNA-sequencing and GC-MS analysis in THP-1 cells with ABAT knockdown. | Cell Death Discovery

Fig. 3: RNA-sequencing and GC-MS analysis in THP-1 cells with ABAT knockdown.

From: ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling

Fig. 3

A Volcano map of differential gene expression in THP-1 cells with ABAT interference. B Heatmap of differential gene expression screened in ABAT silenced THP-1 cells. C Gene Set Enrichment analysis of top two upregulated and downregulated pathways. D KEGG pathway analysis of differentially expressed genes. E The metabolic pathway of ABAT gene involved in disease. F ABAT gene-related pathway was analyzed using KEGG. G Heatmap of differential metabolites screened in ABAT silenced THP-1 cells. H Volcano map of differential metabolites in THP-1 cells with ABAT knockdown. I KEGG pathway analysis of differential metabolites. J Representative differential metabolites were analyzed between NC and ABAT knockdown groups. Data were shown as mean ± SEM from three biological samples. *P < 0.05, **P < 0.01. Student’s t-test was used in two-group comparisons.

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